%20%D0%B1%D0%B5%D0%B7%20%D0%BE%D1%87%D0%B8%D1%81%D1%82%D0%BA%D0%B8%20%E2%80%94%20%D0%BA%D0%BE%D0%BF%D0%B8%D1%8F.jpg "Chemists Simplify Synthesis of Drugs Involving Amide Groups")
Chemists Simplify Synthesis of Drugs Involving Amide Groups
Chemists from HSE University and the Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences (INEOS RAS) have developed a new method for synthesising amides, essential compounds in drug production. Using a ruthenium catalyst and carbon monoxide under precisely controlled reaction conditions, they successfully obtained the target product without by-products or complex purification steps. The method has already been tested for synthesising a key component of Vorinostat, a drug used to treat T-cell lymphoma. This approach could lower the cost of the drug by orders of magnitude. The paper has been published in the Journal of Catalysis. The study was supported by the Russian Science Foundation.
Russian Scientists Develop New Compound for Treating Aggressive Tumours
A team of Russian researchers has synthesised a novel compound for boron neutron capture therapy (BNCT), a treatment for advanced cancer that uses the boron-10 isotope. The compound exhibits low toxicity, excellent water solubility, and eliminates the need for administering large volumes. Most importantly, the active substance reaches the tumour with minimal impact on healthy tissues. The study was published in the International Journal of Molecular Sciences shortly before World Cancer Day, observed annually on February 4.