%20%D0%B1%D0%B5%D0%B7%20%D0%BE%D1%87%D0%B8%D1%81%D1%82%D0%BA%D0%B8%20%E2%80%94%20%D0%BA%D0%BE%D0%BF%D0%B8%D1%8F.jpg "Chemists Simplify Synthesis of Drugs Involving Amide Groups")
Chemists Simplify Synthesis of Drugs Involving Amide Groups
Chemists from HSE University and the Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences (INEOS RAS) have developed a new method for synthesising amides, essential compounds in drug production. Using a ruthenium catalyst and carbon monoxide under precisely controlled reaction conditions, they successfully obtained the target product without by-products or complex purification steps. The method has already been tested for synthesising a key component of Vorinostat, a drug used to treat T-cell lymphoma. This approach could lower the cost of the drug by orders of magnitude. The paper has been published in the Journal of Catalysis. The study was supported by the Russian Science Foundation.
Scientists Present New Solution to Imbalanced Learning Problem
Specialists at the HSE Faculty of Computer Science and Sber AI Lab have developed a geometric oversampling technique known as Simplicial SMOTE. Tests on various datasets have shown that it significantly improves classification performance. This technique is particularly valuable in scenarios where rare cases are crucial, such as fraud detection or the diagnosis of rare diseases. The study's results are available on ArXiv.org, an open-access archive, and will be presented at the International Conference on Knowledge Discovery and Data Mining (KDD) in summer 2025 in Toronto, Canada.
Implementation of Principles of Sustainable Development Attracts More Investments
Economists from HSE and RUDN University have analysed issues related to corporate digital transformation processes. The introduction of digital solutions into corporate operations reduces the number of patents in the field of green technologies by 4% and creates additional financial difficulties. However, if a company focuses on sustainable development and increases its rating in environmental, social, and governance performance (ESG), the negative effects decrease. Moreover, when the ESG rating is high, digitalisation can even increase the number of patents by 2%. The article was published in Sustainability.
Russian Scientists Develop New Compound for Treating Aggressive Tumours
A team of Russian researchers has synthesised a novel compound for boron neutron capture therapy (BNCT), a treatment for advanced cancer that uses the boron-10 isotope. The compound exhibits low toxicity, excellent water solubility, and eliminates the need for administering large volumes. Most importantly, the active substance reaches the tumour with minimal impact on healthy tissues. The study was published in the International Journal of Molecular Sciences shortly before World Cancer Day, observed annually on February 4.
HSE Scientists Develop Application for Diagnosing Aphasia
Specialists at the HSE Centre for Language and Brain have developed an application for diagnosing language disorders (aphasia), which can result from head injuries, strokes, or other neurological conditions. AutoRAT is the first standardised digital tool in Russia for assessing the presence and severity of language disorders. The application is available on RuStore and can be used on mobile and tablet devices running the Android operating system.
HSE Scientists Take Important Step Forward in Development of 6G Communication Technologies
Researchers at HSE MIEM have successfully demonstrated the effective operation of a 6G wireless communication channel at sub-THz frequencies. The device transmits data at 12 Gbps and maintains signal stability by automatically switching when blocked. These metrics comply with international 6G standards. An article published on arXiv, an open-access electronic repository, provides a description of certain elements of the system.